GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs56016656 | chr7:65383481 | CCT6P1 | chr7:65216092-65228661:+ | 0.7 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs17761864 | 1 | rs56043407 | chr17:2166078 | SRR | chr17:2207248-2228553:+ | -0.53 | -5.51 | 3.02E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs9815354 | 1 | rs56121764 | chr3:41883975 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.51 | 1.88E-15 | Diastolic blood pressure |
| THYM | cis | rs9309473 | 1 | rs56154726 | chr2:73721767 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.59 | 1.34E-5 | Metabolite levels |
| THYM | cis | rs12220898 | 1 | rs56157536 | chr10:50610008 | PGBD3 | chr10:50723247-50747584:- | -0.69 | -4.23 | 5.4E-5 | Inflammatory biomarkers |
| THYM | cis | rs9815354 | 1 | rs56158380 | chr3:41885588 | ULK4 | chr3:41288091-42003660:- | 0.96 | 9.51 | 1.88E-15 | Diastolic blood pressure |
| THYM | cis | rs60843830 | 1 | rs56167434 | chr2:282137 | SH3YL1 | chr2:218138-264810:- | -0.34 | -4.91 | 3.83E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9815354 | 1 | rs56207540 | chr3:41976627 | ULK4 | chr3:41288091-42003660:- | 1.09 | 7.15 | 1.75E-10 | Diastolic blood pressure |
| THYM | cis | rs1875620 | 1 | rs56261853 | chr9:91563353 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.23 | 5.4E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs2243480 | 1 | rs56291018 | chr7:65390339 | CCT6P1 | chr7:65216092-65228661:+ | 0.7 | 5.13 | 1.51E-6 | Diabetic kidney disease |
| THYM | cis | rs3772130 | 1 | rs56314138 | chr3:121356656 | IQCB1 | chr3:121488610-121553926:- | 0.48 | 4.47 | 2.2E-5 | Cognitive performance |
| THYM | cis | rs60843830 | 1 | rs56321614 | chr2:268191 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs4802666 | 1 | rs56354891 | chr19:50727510 | NAPSB | chr19:50837059-50848005:- | -0.32 | -4.59 | 1.37E-5 | Disc degeneration (lumbar) |
| THYM | cis | rs67366981 | 1 | rs56357623 | chr14:77697393 | NGB | chr14:77731834-77737655:- | -0.42 | -4.23 | 5.33E-5 | Obsessive-compulsive symptoms |